Creighton Blue Jays vs DePaul Blue Demons: NCAA Spread and Total Betting Outlook

Pre-bet checklist

The core betting markets for this game will likely feature Creighton as a sizeable home favorite on the moneyline, with the spread potentially in the -12.5 to -18.5 range depending on injury news and recent performance. Totals for matchups like this often open in the 146.5 to 154.5 points band, reflecting Creighton’s offensive ceiling and DePaul’s defensive vulnerabilities.

Additional info

A slight lean could be toward Creighton to cover a mid-teens spread if the Blue Jays’ starting backcourt and primary rim protector are confirmed available, since DePaul has historically struggled to generate efficient half-court looks and can suffer extended scoring droughts. Market movement is worth tracking; a sharp move toward Creighton or an upward push on the total would suggest early confidence in the home offense.

Quarter and first-half lines may also provide opportunities if DePaul’s depth issues continue to show early.

Before betting, confirm official injury reports, starting lineups, and any minutes restrictions for key guards and bigs on both sides. Clarify your sportsbook’s settlement rules for spreads and totals, including how overtime scoring is handled, and check account limits or reduced limits on college basketball.