Charleston Southern vs Winthrop Betting Analysis and Odds for NCAA Clash

From a betting perspective, the core markets are moneyline, spread, and total points, although the prediction section below is mapped to a standardized market type. If Winthrop enters as a road favorite, a typical spread band could sit around -6.5 to -10.5 depending on injuries and recent form, with some books shading slightly toward Winthrop if their offense has been efficient from three. Total points may open in a higher range for a mid-major, roughly equivalent to games that project as moderately fast-paced, with line movement reacting to any late injury news to key guards.

Winthrop has generally held the recent head-to-head edge and typically plays at a more efficient offensive level than Charleston Southern, especially when forcing turnovers and converting in transition. If current-season trends follow historical Big South patterns, Winthrop’s depth and tempo give it a moderate advantage straight up, particularly if its perimeter shooting is near conference average and Charleston Southern continues to show defensive inconsistency.